Biology
epitope
Term: epitope
Origin: Anc Greek
???-/epi(=prefix meaning upon, on)
?????/topos(=place, location)
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Niels Kaj Jerne (1911-1994) |
Coined: in 1960 by Danish immunologist Niels Kaj Jerne (1911?1994) who proposed that an antigen particle carries several epitopes.
Definition:
The surface portion of an antigen which is recognised by immune system (antibodies, B or T cells) and elicit an immune response. The part of an antibody that recognizes the epitope is called a paratope.
Sourses
Jerne, N.K. (1974), "Towards a network theory of the immune System", Ann. Immunol. (Paris) 125C: 373?389
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# 60 Action Of B-lymphocytes
A B-lymphocyte places some of its specific receptor molecules in its cell surface membrane. If it encounters an antigen that binds with this receptor, the B-lymphocyte is activated. It divides repeatedly by mitosis to produce a clone of genetically identical plasma...
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#59 The Immune Response - Lymphocytes
Lymphocytes, unlike phagocytes, act against specific pathogens. Each lymphocyte contains a set of genes that codes for the production of a particular type of receptor. We have many million different types, each producing just one type of receptor....
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#57.2 Immunity - Syllabus 2016
11.1 The immune system 11.2 Antibodies and vaccination An understanding of the immune system shows how cells and molecules function together to protect the body against infectious diseases and how the body is protected from further...
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#57 Immunity - Syllabus 2015
? The immune system ? Vaccination Candidates should be able to: (a) [PA] recognise phagocytes and lymphocytes under the light microscope; (b) state the origin and describe the mode of action of phagocytes (macrophages and neutrophils); (c) describe...
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Hapten
Term: hapten (parial or incomplete antigen) ???? Origin: Anc Greek????/hapto (=fasten, adapt, clasp, bind or grasp) ?? Karl Landsteiner?? ? ???Coined: in 1921 by the American biologist of Austrian origin, Karl Landsteiner (1868 ? June 26, 1943). In 1930,...
Biology