epitope
Biology

epitope


Term: epitope

Origin: Anc Greek
???-/epi(=prefix meaning upon, on)
?????/topos(=place, location)

Niels Kaj Jerne (1911-1994)
Coined: in 1960 by Danish immunologist Niels Kaj Jerne (1911?1994) who proposed that an antigen particle carries several epitopes.

Definition:
The surface portion of an antigen which is recognised by immune system (antibodies, B or T cells) and elicit an immune response. The part of an antibody that recognizes the epitope is called a paratope.

Sourses
Jerne, N.K. (1974), "Towards a network theory of the immune System", Ann. Immunol. (Paris) 125C: 373?389




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- Hapten
Term: hapten (parial or incomplete antigen) ???? Origin: Anc Greek????/hapto (=fasten, adapt, clasp, bind or grasp) ?? Karl Landsteiner?? ? ???Coined: in 1921 by the American biologist of Austrian origin, Karl Landsteiner (1868 ? June 26, 1943). In 1930,...



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