angiostatin
Biology

angiostatin




Term: angiostatin
Literally meaning: ?protein of blocking blood vessels?
Origin: Anc Greek
??????/angio(=vessel, receptacle) >  ?????/aggos(=tube)
+??????/histimi(=stand) >??????/stasis(=halt)
Coined/History 
Angiostatin was observed initially in 1994 as an angiogenesis inhibitor in serum and urine of mice bearing a Lewis lung carcinoma. The same research group  reffered that plasminogen yields distinct angiostatins which have been termed angiostatin -1 and angiostatin-2.
Sources
         O?Reilly M. S., Holmgren L., Shing Y., Chen C., Rosenthal R. A., Moses M. A.,       
            Lane W. S., Cao Y.,Sage E. H.,Folkman J. (1994) Cell 79:315?328
Definition
An endogenous protein that inhibits endothelial proliferation and was identified as an 38 kDa  internal fragment of plasminogen.  





- Angiogenin (ang-1)
Term: angiogenin (Ang-1) or ribonuclease 5 Literally meaning: ?that produces vessels?Origin: Anc Greek??????/aggio (=vessel, receptacle) > ?????/aggos(=tube)+?????/geno(= ?produce?, ?give birth to?, ?create?)Coined/HistoryThe term angiogenesis was...

- Angiogenesis
Term: angiogenesisLiterally meaning: ?production of new vessels?Origin: Anc Greek??????/aggio (=vessel, receptacle) >  ?????/aggos(=tube)+???????/genesis(=origin) > ?????/geno(= ?to produce?, ?to give birth to?, ?to create?) Coined/History...

- Chitinase
Term: chitinaseLiterally meaning: ?an enzyme that breaks down chitin?Origin: Anc Greek?????/chiton(=tunic)+(-???)/(-asy)(=-ase) enzyme suffix added to the name of the substrate that the enzyme  hydrolyzes eg proteinase for protein or lipase for...

- Hemangioma
Term: hemangiomaLiterally meaning: tumor of blood vesselsOrigin: Anc Greek????/hema(=blood)??????/angio(=vessel, receptacle) >  ?????/aggos(=tube)-???/-oma(=condition of a disease such as in tumors)Coined/History(?)Liebow and Hubbell first described...

- Coagulation Factors And Related Substances
Number and/or name Function Associated genetic disorders I (Fibrinogen) Forms clot (fibrin) Congenital afibrinogenemia, Familial renal amyloidosis II (Prothrombin) Its active form (IIa) activates I, V, VII, VIII, XI, XIII,...



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