Biology
A competitive inhibitor is structurally similar to the substrate but a non-competitive inhibitor is often structurally different from the substrate. Hence, a competitive inhibitor will compete with the substrate for an active site but a non competitive inhibitor will bind to the allosteric site of the enzyme, away from the active site. A competitive inhibitor does not change the three dimensional (secondary and tertiary structure) of an enzyme, but a non-competitive inhibitor always changes its structure. A competitive inhibitor will not affect the active site of the enzyme, but a non-competitive inhibitor will alter the active site of the enzyme such that it is no longer complementary in size, shape, and charge to the substrate. The effects of competitive inhibition can be overcome but increasing substrate concentration, thus increasing the chance of forming enzyme-substrate complex but the effects of non-competitive inhibition cannot be overcome by increasing substrate concentration, but only by increasing enzyme concentration. The effects of competitive inhibition are usually temporary but the effects of the non-competitive inhibition are permanent.
- Q: Explain The Effects Of Too High A Temperature On An Enzyme
If the temperature is too high, an increase in kinetic energy of the molecules will cause excessive vibrations of the molecules. This will disrupt the 3 dimensional structure of the enzyme, causing it to become a random coil. The enzyme is therefore denatured....
- #20.factors Affecting The Rate Of Enzyme-catalysed Reactions
These factors are: - Temperature - pH - Enzyme concentration - Substrate concentration - Inhibitor concentration When an enzyme solution is added to a solution of its substrate, the molecules collide. With time, the quantity of substrate...
- #17.2 Enzymes - Syllabus 2016
3.1 Mode of action of enzymes 3.2 Factors that affect enzyme action Enzymes are essential for life to exist. Their mode of action and the factors that affect their activity are explored in this section. Prior...
- #17.1 Enzymes - Syllabus 2015
? Mode of action of enzymes ? Factors that affect enzyme action Learning Outcomes Candidates should be able to: (a) explain that enzymes are globular proteins that catalyse metabolic reactions; (b) explain the mode of action of enzymes in terms of...
- Enzymes
ENZYMES Enzymes are biological catalysts which influence biochemical reactions. All enzymes are proteins but all proteins are not enzymes because there are proteins other than enzymes. Ribozymes: These are the Nucleic acids (RNA) that behave like...
Biology
Q: Distinguish between competitive and non-competitive inhibition of enzymes
A competitive inhibitor is structurally similar to the substrate but a non-competitive inhibitor is often structurally different from the substrate. Hence, a competitive inhibitor will compete with the substrate for an active site but a non competitive inhibitor will bind to the allosteric site of the enzyme, away from the active site. A competitive inhibitor does not change the three dimensional (secondary and tertiary structure) of an enzyme, but a non-competitive inhibitor always changes its structure. A competitive inhibitor will not affect the active site of the enzyme, but a non-competitive inhibitor will alter the active site of the enzyme such that it is no longer complementary in size, shape, and charge to the substrate. The effects of competitive inhibition can be overcome but increasing substrate concentration, thus increasing the chance of forming enzyme-substrate complex but the effects of non-competitive inhibition cannot be overcome by increasing substrate concentration, but only by increasing enzyme concentration. The effects of competitive inhibition are usually temporary but the effects of the non-competitive inhibition are permanent.
- Q: Explain The Effects Of Too High A Temperature On An Enzyme
If the temperature is too high, an increase in kinetic energy of the molecules will cause excessive vibrations of the molecules. This will disrupt the 3 dimensional structure of the enzyme, causing it to become a random coil. The enzyme is therefore denatured....
- #20.factors Affecting The Rate Of Enzyme-catalysed Reactions
These factors are: - Temperature - pH - Enzyme concentration - Substrate concentration - Inhibitor concentration When an enzyme solution is added to a solution of its substrate, the molecules collide. With time, the quantity of substrate...
- #17.2 Enzymes - Syllabus 2016
3.1 Mode of action of enzymes 3.2 Factors that affect enzyme action Enzymes are essential for life to exist. Their mode of action and the factors that affect their activity are explored in this section. Prior...
- #17.1 Enzymes - Syllabus 2015
? Mode of action of enzymes ? Factors that affect enzyme action Learning Outcomes Candidates should be able to: (a) explain that enzymes are globular proteins that catalyse metabolic reactions; (b) explain the mode of action of enzymes in terms of...
- Enzymes
ENZYMES Enzymes are biological catalysts which influence biochemical reactions. All enzymes are proteins but all proteins are not enzymes because there are proteins other than enzymes. Ribozymes: These are the Nucleic acids (RNA) that behave like...