Biology
- Expressed Gene Number Can Be Measured En Masse
KEY CONCEPTS:"Chip" technology allows a snapshot to be taken of the expression of the entire genome in a yeast cell. ~75% (~4500 genes) of the yeast genome is expressed under normal growth conditions. Chip technology allows detailed comparisons of related...
- The Y Chromosome Has Several Male-specific Genes
KEY CONCEPTS:The Y chromosome has ~60 genes that are expressed specifically in testis. The male-specific genes are present in multiple copies in repeated chromosomal segments. Gene conversion between multiple copies allows the active genes to be maintained...
- The Human Genome Has Fewer Genes Than Expected
KEY CONCEPTS:Only 1% of the human genome consists of coding regions. The exons comprise ~5% of each gene, so genes (exons plus introns) comprise ~25% of the genome. The human genome has 30,000-40,000 genes. ~60% of human genes are alternatively spliced....
- The Content Of The Genome
KEY TERMS:The genome is the complete set of sequences in the genetic material of an organism. It includes the sequence of each chromosome plus any DNA in organelles. The transcriptome is the complete set of RNAs present in a cell, tissue, or organism....
- Genome
Term: genomeOrigin: Anc Greek ?????/ genea(=generation) < ?????/geno (=give birth to)-???/oma(=ome) Coined: In 1920 by German botanist Hans Winkler (1877 -1945) defined ?genome? as ?for the haploid chromosome set? in his...
Biology
metabonomics, metabolonomics
Term: metabonomics, metabolonomics
Origin: Anc Greek
????????/metaboli(=change)
?????/nomos(=law)
-omics is a suffix which originally was used in word ?genomics> genome =gene + chromosome in order to indicate the complete set of chromosomes and the genes contained in them. An omics technology has come to mean an approach capable of generating a comprehensive data set of whatever is being measured, be it transcripts (transcriptomics), proteins (proteomics), or metabolites (metabonomics).
Coined:
The actual term of metabonomics was devised by Jeremy Nicholson, Elaine Holmes, and John Lindon of Imperial College (London
The term metabolomics was defined and indicated by Fiehn (2001) to be the ?comprehensive and quantitative analysis of all metabolites. ??
Definition:
Metabonomics or metabolonomics is defined as the quantitative measurement of the time-related multi-parametric metabolic response of living systems (in vivo) to pathophysiological stimuli or genetic modification (Nicholson et al., 1999).
Comment
What is the difference between metabonomics and metabolomics, The matter is more a subject of historical usage than meaningful scientific definition as both are used with the same scientific sense.
- Expressed Gene Number Can Be Measured En Masse
KEY CONCEPTS:"Chip" technology allows a snapshot to be taken of the expression of the entire genome in a yeast cell. ~75% (~4500 genes) of the yeast genome is expressed under normal growth conditions. Chip technology allows detailed comparisons of related...
- The Y Chromosome Has Several Male-specific Genes
KEY CONCEPTS:The Y chromosome has ~60 genes that are expressed specifically in testis. The male-specific genes are present in multiple copies in repeated chromosomal segments. Gene conversion between multiple copies allows the active genes to be maintained...
- The Human Genome Has Fewer Genes Than Expected
KEY CONCEPTS:Only 1% of the human genome consists of coding regions. The exons comprise ~5% of each gene, so genes (exons plus introns) comprise ~25% of the genome. The human genome has 30,000-40,000 genes. ~60% of human genes are alternatively spliced....
- The Content Of The Genome
KEY TERMS:The genome is the complete set of sequences in the genetic material of an organism. It includes the sequence of each chromosome plus any DNA in organelles. The transcriptome is the complete set of RNAs present in a cell, tissue, or organism....
- Genome
Term: genomeOrigin: Anc Greek ?????/ genea(=generation) < ?????/geno (=give birth to)-???/oma(=ome) Coined: In 1920 by German botanist Hans Winkler (1877 -1945) defined ?genome? as ?for the haploid chromosome set? in his...