Biology

erythropoeietin

Term:erythropoietin

Literally meaning: ?protein of making erythrocytes?

Origin: Anc Greek

???????/erythros(=red)

+?????/poieo (=create, make)

Coined/History

The concept of a hormone that regulates red blood cell production was proposed in 1906 by Paul Camot and DeFlandres who observed that serum from anemic donor rabbit injected into normal rabbits could lead to erythropoiesis.. The name was introduced by Eva Bonsdorff and Eeva Jalavisto, in 1948, after studying red cell production in animals. Hematologists John Adamson and nephrologist Joseph W Eschbach looked at the role of the natural hormone EPO in the formation of red blood cells and could help to a treatment to anaemia. Finally in 1985 the human erythropoietin gene was cloned by Jacobs et al., and a large scale production began. In 1987 a clinical trial was conducted for a synthetic form of the hormone, Epogen produced by Amgen

Sources

1. Carnot M, De?andre C. Comptes Rendus Hebdomadaires desSeances de l?Acad des Sci. 1906;143:384-386.

2. Eva Bonsdorff, eeva Jalavisto A Humoral Mechanism in Anoxic Erythrocytosis

Acta Physiologica Scandinavica, Volume 16, Issue 2-3, pages 150?170, November 1948

3. Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW (January 1987). "Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial". N. Engl. J. Med. 316 (2): 73?8.

4.Jacobs K, Shoemaker C, Rudersdorf R, et al. Isolation andcharacterization of genomic and cDNA clones of humanerythropoietin. Nature 1985;313(6005):806-10

Definition

Erythropoetin is a glycoprotein produced by kidney that stimulates precursor erythrocytes proliferation in bone marrow.

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