| Artery | Vein |
| 1. Direction of blood flow is from heart to other body parts | Direction of blood flow is from body parts to heart |
| 2. Carries oxygenated (pure) blood (except in pulmonary artery) | Carries deoxygenated (impure) blood (except in pulmonary vein) |
| 3. Blood flows in high pressure and speed | Blood flows in low pressure and speed |
| 4. Thicker and more elastic wall | Thinner and less elastic |
| 5. Narrow lumen | Wide lumen |
| 6. Deep seated in position | Generally found superficial in position |
| 7. Valves are absent | Present |
| 8. Tunica interna (innermost layer) is more developed and elastic. Elongated endothelial cells are present in this layer | Tunica interna is less developed and elastic. Endothelial cells are less flat |
| 9. Tunica media (middle layer) is more muscular with many elastic fibres | Tunica media is less muscular with few elastic fibres |
| 10. Tunica externa (outermost layer) is less developed so less strong | Tunica externa is more developed so more strong |
| 11. After death, arteries become empty | After death, veins will contain blood |