#113 The control of blood glucose

The blood glucose concentration is regulated by negative feedback control mechanisms.









Blood glucose concentration should remain at a fairly constant value of about 100 mg glucose per 100 cm3 of blood.

• If blood glucose concentration falls well below this level, the person is said to be hypoglycaemic. Cells do not have enough glucose to carry out respiration, and so metabolic reactions may not be able to take place and the cells cannot function normally. This is especially so for cells such as brain cells, which can only use glucose and not other respiratory substrates. The person may become unconscious and various tissues can be damaged.
• If blood glucose concentration rises well above this level, the person is said to be hyperglycaemic. The high glucose concentration decreases the water potential of the blood and tissue fluid, so that water moves out of cells down a water potential gradient. Again, unconsciousness can result.

Several hormones are involved in the control of blood glucose concentration by negative feedback. They include insulin and glucagon.

Both of these are small proteins. They are secreted by patches of tissue called islets of Langerhans in the pancreas. Insulin is secreted by ? cells. Glucagon is secreted by ? cells.

After eating a meal, blood glucose rises:

? Food eg. starch are hydrolyzed by digestive enzymes into glucose
? Glucose is absorbed across the gut wall into the blood capillaries
? Rise in blood glucose detected by ?-cells of islets of langerhans in the pancreas
? Insulin is secreted into the bloodstream
? Promotes the uptake of glucose by the liver and muscle cells
? Glucose then converted to glycogen

During exercise, blood glucose concentration falls:

? Detected by ?- and ?-cells of islets of langerhans in the pancreas
? Fall inhibits further insulin secretion
? Secretion of glucagons by ?-cells into the blood
? Binds to receptors on liver cell surface membrane
? Activation of phosphorylase
? Promotes conversion of glycogen to glucose in the liver (glycogenolysis)
? Promotes gluconeogenesis, the production of glucose
? Glucose is released into the bloodstream
? Fats are broken down and respired.

Source: Pearson Education.

14.1  Homeostasis in mammals Homeostasis in mammals requires complex systems to maintain  internal conditions near  constant. The kidneys  remove wastes from the blood and are the effectors for controlling the water potential of the blood. a)   discuss the importance of homeostasis in mammals and explain the principles  of homeostasis in terms of internal and external stimuli, receptors, central  control,  co-ordination systems, effectors (muscles and glands) b)   define  the term  negative feedback and explain how it is involved in homeostatic mechanisms c)   outline  the roles of the nervous system and endocrine system in co-ordinating homeostatic mechanisms, including thermoregulation, osmoregulation and the control of blood glucose concentration d)   describe the deamination of amino  acids  and outline  the formation of urea  in the urea  cycle (biochemical detail of the urea  cycle is not required) e)   describe the gross structure of the kidney and the detailed structure of the nephron with its associated blood vessels using photomicrographs and electron micrographs f) describe how the processes of ultrafiltration and selective reabsorption are involved with the formation of urine in the nephron g)   describe the roles of the hypothalamus, posterior pituitary, ADH and collecting  ducts in osmoregulation h)   explain how the blood glucose concentration is regulated by negative feedback control mechanisms, with reference to insulin and glucagon i) outline  the role of cyclic AMP as a second messenger with reference to the stimulation of liver cells by adrenaline and glucagon j) describe the three main stages of cell signalling in the control of blood glucose by adrenaline as follows: ?   hormone-receptor interaction at the cell surface ?   formation of cyclic AMP which binds to kinase  proteins ? an enzyme cascade involving activation  of enzymes by phosphorylation to amplify the signal k)   explain the principles  of operation of dip sticks  containing glucose oxidase and peroxidase enzymes, and biosensors that can be used for quantitative measurements of glucose in blood and urine l) explain how urine analysis  is used in diagnosis with reference to glucose, protein  and ketones

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