Biology
- Intro To Cancer
Cancer starts as a genetic mutation in a few cells. The mutation can be due to radiation or some genetic problem. The cells then reproduce without stopping. The cancer cells find a place and then continue to reproduce until they create a tumor. The image...
- Mitochondria Evolved By Endosymbiosis
How did a situation evolve in which an organelle contains genetic information for some of its functions, while others are coded in the nucleus? Figure 3.41 shows the endosymbiosis model for mitochondrial evolution, in which primitive cells captured bacteria...
- Genetic Information Can Be Provided By Dna Or Rna
KEY TERMS:The central dogma describes the basic nature of genetic information: sequences of nucleic acid can be perpetuated and interconverted by replication, transcription, and reverse transcription, but translation from nucleic acid to protein is unidirectional,...
- Cancer: Types, Causes, Diagnosis And Treatment
CANCER · Cancer is an abnormal and uncontrolled multiplication of cells resulting in the formation of tumor.· Normal cells show a contact inhibition (contact with the other cells inhibits their uncontrolled growth)....
- 2/20/14
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Biology
oncogene
Term: oncogene
Literally meaning: ?cancer gene?
Origin: Anc Greek
?????/ogos(=volume) > ????? /ogoo(=raise, establish)
?????/ genea(=generation) > ?????/geno (=birth to) >
Coined/History
In 1969, Robert Huebner and George Todaro proposed the ?oncogene? hypothesis proposing that special parts of the genetic material of certain RNA viruses could be transmitted genetically. They postulated that some of these endogenous viruses contained transforming genes or 'oncogenes,' and that activation of these endogenous transforming viruses could cause cancer (Huebner and Todaro, Proc. Natl. Acad. Sci. USA, 64, 1087?1094. 1969). The term ?proto-oncogene? was coined to identify the cellular precursor of a such retroviral transforming gene; the term was chosen to distinguish these genes from the ?oncogenes?. c-src (derived from ?cellular sarcoma?) was the first of several proto-oncogenes to be discovered in the vertebrate genome. By 1984, over 20 oncogenes had been discovered .
Definition
An oncogene is a mutated form of normal gene (proto-oncogene) that control cell growth and it has the potential to cause cancer after its overexpression.
- Intro To Cancer
Cancer starts as a genetic mutation in a few cells. The mutation can be due to radiation or some genetic problem. The cells then reproduce without stopping. The cancer cells find a place and then continue to reproduce until they create a tumor. The image...
- Mitochondria Evolved By Endosymbiosis
How did a situation evolve in which an organelle contains genetic information for some of its functions, while others are coded in the nucleus? Figure 3.41 shows the endosymbiosis model for mitochondrial evolution, in which primitive cells captured bacteria...
- Genetic Information Can Be Provided By Dna Or Rna
KEY TERMS:The central dogma describes the basic nature of genetic information: sequences of nucleic acid can be perpetuated and interconverted by replication, transcription, and reverse transcription, but translation from nucleic acid to protein is unidirectional,...
- Cancer: Types, Causes, Diagnosis And Treatment
CANCER · Cancer is an abnormal and uncontrolled multiplication of cells resulting in the formation of tumor.· Normal cells show a contact inhibition (contact with the other cells inhibits their uncontrolled growth)....
- 2/20/14
...